Skip to main content
  • Home
  • Zylkene Calming Supplement for Dogs 15-60kg - 100 capsules

Zylkene Calming Supplement for Dogs 15-60kg - 100 capsules By Zylkene

10Reviews
Price per Bag

RRP £202.80

2 BagsBottomless Bowl£188.99Free Delivery-7%
2 BagsOne Time Purchase£188.99Free Delivery-7%
1 BagBottomless Bowl£190.99Free Delivery-6%
1 BagOne Time Purchase£190.99Free Delivery-6%

Subscribe & Save Time with Subscription

Learn more

✔ In Stock, Get it Tuesday
Order within 20mins 6secs
Zylkene 450mg is a calming supplement for large dogs weighing 15–60kg, designed to help them cope with short-term challenging situations such as loud noises, social gatherings, travelling, vet visits or changes in routine. Containing a natural milk protein with clinically proven calming effects, it helps support emotional balance without causing drowsiness and can be easily given by opening the capsule and sprinkling the powder onto food.
  • Helps dogs cope with short-term challenging or stressful situations
  • Contains a natural milk protein with clinically proven calming effects
  • Supports emotional balance without causing drowsiness
  • Easy-to-administer capsules that can be opened and mixed with food
  • UK’s No.1 veterinary calming supplement, widely used and trusted by vets
Powder: Casein (trypsin hydrolysed bovine casein), magnesium stearate. Capsule: Bovine skin gelatine.
Powder: Casein (trypsin hydrolysed bovine casein) 82.9%, magnesium stearate.
Capsule: Bovine skin gelatine 17.1%.
Short-term use: Begin 1–2 days before the expected stressful event.

Longer-term use: Give daily for 1 month, then reassess behaviour and continue if needed.

Daily Amount:
15–30kg body weight: 1 capsule per day
30–60kg body weight: 2 capsules per day

The capsule can be opened and mixed with food. Always ensure clean, fresh water is available.
Store in a cool, dry place.

Ratings & Reviews

10 reviews

  • 3 stars
  • 0 reviews
  • 2 stars
  • 0 reviews
  • 1 star
  • 0 reviews
5/8/2025 6:46:00 AM

Noticeably happier dog

by Joel Adams -

He seems genuinely much happier and more comfortable in his own skin now.

1/5/2025 1:53:00 PM

Highly recommend

by Iris Wilson -

An excellent gentle and effective solution for anxiety in larger dogs.

14/7/2025 2:12:00 PM

Expensive but worth it

by Harry Taylor -

It's a significant cost but the improvement in his quality of life is completely worth the price.

29/5/2025 7:40:00 PM

Essential for stressful events

by Gail Scott -

This is a must have for vet visits house moves or any known high stress situations.

4/6/2025 5:37:00 PM

Natural calmness

by Fred Riley -

He is much more relaxed without being at all sluggish or out of it Great natural relief.

6/5/2025 4:17:00 PM

Long lasting supply

by Emily Perez -

The 100 capsule bottle is perfect for my large dog's daily needs and lasts for a good few months.

16/6/2025 8:56:00 PM

Vet approved supplement

by David Oliver -

My vet gave the go ahead for this supplement and I've been happy with the progress.

23/7/2025 3:24:00 PM

Easy to use dosage

by Clara Newman -

The large dog capsules make dosing very simple No need to mess around with multiple small pills.

21/10/2025 8:28:00 AM

Great for nervous reactivity

by Ben Martin -

I combine this with training and his reactions to strangers and dogs are much less intense now.

20/5/2025 11:17:00 AM

Works for my big dog

by Alice Lee -

My large breed dog is prone to anxiety and these large dog capsules really help.