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Advantage 400 Spot On Flea Control Extra Large Dog (25-40kg) - 4 Pack By Advantage




Advantage Spot-On Flea Treatment Key Features

  • Up to 4 weeks of protection in cats and dogs and 1 week in rabbits
  • Kills fleas through contact*
  • Vet-recommended flea treatment
  • Suitable for use on extra large dogs between 25 - 40kg
  • Easy to apply
  • Starts working within 1 day.
  • Why Worry About Fleas?

    Aside from causing irritation, fleas can lead to Flea Allergy Dermatitis (FAD) and even anaemia in serious cases. Infected fleas can also transmit tapeworm if swallowed during grooming.

    Fleas bite humans too. Home infestations can take months to clear because only 5% of fleas live on your pet. The other 95% are in your home environment as eggs, larvae and pupae.

    One application of Advantage remains effective for up to 4 weeks in pets and up to one week in rabbits.

How to Apply Advantage

For dogs < 25kg: Part the coat between the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze firmly several times to empty the contents directly onto the skin.
For dogs > 25kg: The entire contents of the Advantage® tube should be applied evenly to three to four spots on the top of the back from the shoulder to the base of the tail.

See Our Range

Advantage 40 Spot On Flea Control Small Dogs, Cats and Rabbits (<4kg) - 4PackAdvantage 80 Spot On Flea Control Large Cats and Rabbits (4kg+) - 4PackAdvantage 100 Spot On Flea Control Medium Dog (4-10kg) - 4PackAdvantage 250 Spot On Flea Control Large Dog (10-25kg) - 4PackAdvantage 400 Spot On Flea Control Extra Large Dog (25-40kg) - 4Pack



How often should I use Advantage?

It is recommended that you apply Advantage to your dog once a month all year round to achieve protection from fleas.

Can I use Advantage to treat louse infestations?

Yes, Advantage for dogs can be used to treat biting lice in addition to fleas. You should book a check-up with your vet 30 days after treatment, as some dogs may need a second treatment to clear up the louse infestation fully.

How long do I need to wait after bathing my dog before I apply Advantage flea treatment?

If you’ve recently bathed your dog, it’s recommended you wait at least two days before treating them with Advantage flea drops.

Can I allow my pet to swim when using Advantage?

Yes. The active ingredient in Advantage sits in the waterproof layer of your dog’s skin and the product remains effective if your dog becomes wet on occasion (for example after exposure to heavy rain or swimming). However, re-treatment may be necessary on some occasions, for example if your dog is a frequent swimmer; in these cases do not treat more frequently than once weekly.

Can Advantage be used to treat Flea Allergy Dermatitis in my dog?

Flea Allergy Dermatitis (FAD) is an allergic reaction some dogs suffer with when they come into contact with flea saliva as a result of flea bites. It causes dogs to scratch and bite their skin to relieve the extreme irritation. This can lead to hair loss, skin ‘hot spots’ or nasty infections.

Advantage spot-on flea treatment can be used as part of a treatment strategy for Flea Allergy Dermatitis, where this has previously been diagnosed by a veterinary surgeon. The active ingredient in Advantage is able to kill fleas through contact, meaning they don’t have to bite your dog in order to be killed.1 This means dogs are less exposed to the saliva they’re allergic to, helping to reduce FAD outbreaks.

Please note: This is an NFA-VPS product, please fill in your pet details at the checkout so our veterinary medicines manager can approve use and avoid the order being delayed.


*This information is regarding mode of action and is not intended to imply fleas can be completely stopped from biting.


Use Medicine Responsibly: Advantage ® contains imidacloprid [NFA-VPS].

Further information from the datasheet at www.advantagespoton.co.uk or on request.

® Registered trademark of Bayer AG. Bayer plc, 400 South Oak Way, Green Park, Reading, RG2 6AD. Tel: 0118 206 3000


Please note: This is a NFA-VPS product, please fill in your pet details at checkout so our Veterinary Medicines manager can approve use and avoid the order being delayed. Please click here for the Veterinary Medicines Directorate for further information on this product.

For the prevention and treatment of flea infestations and for the treatment of biting lice on dogs of 4-10 kg body weight. Fleas on dogs are killed within one day following treatment. One treatment prevents further flea infestation for four weeks. The product can be used as part of a treatment strategy for the control of Flea Allergy Dermatitis (FAD) where this has been previously diagnosed by a veterinary surgeon.

Administration Instructions

Dog Weight (kg)


Number of Pipettes

< 4kg

Use Advantage 40

1 x 0.4 ml

4 - 9kg

Use Advantage 100

1 x 1.0 ml

10 - 24kg

Use Advantage 250

1 x 2.5 ml

25 - 39kg

Use Advantage 400

1 x 4.0 ml

≥ 40kg

Use Advantage 400

2 x 4.0 ml

Animals should be weighed before treatment.

Remove one pipette from the package. Hold pipette in an upright position, twist and pull off cap. Use reversed cap to twist and remove seal from pipette. The dog should be standing for easy application. The entire contents of the pipette(s) should be applied evenly to three or four spots all located at different application sites along the dog’s backline from the shoulder to the base of the tail. At each spot part the coat until the skin is visible. Place the tip of the pipette on the skin and gently squeeze to expel a portion of the contents directly onto the skin.

The product is bitter tasting and salivation may occa­sionally occur if the dog licks the application site immediately after treatment and should disappear within some minutes. Apply only to undamaged skin. Do not allow recently treated animals to groom each other.

Do not treat again within 4 weeks.

Use during pregnancy or lactation

Evidence so far suggests that no adverse effects are expected in pregnant or lactating bitches.


Do not treat unweaned puppies of less than 8 weeks of age.

Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients.


This product is for topical use and should not be administered orally.

Care should be taken to avoid the contents of the pipette coming into contact with the eyes or mouth of the animal.

Do not allow recently treated animals to groom each other.

Wash hands thoroughly after use.

Wash off any skin contamination with soap and water.

People with known skin sensitivity may be particularly sensitive to this product.

Avoid contact of the product with the eyes or mouth.

If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water. If skin or eye irritation persists, or the product is accidentally swallowed, obtain medical attention.

Do not eat, drink or smoke during application.

Adverse Reactions

The product is bitter tasting and salivation may occa­sionally occur if the dog licks the application site immediately after treatment. This is not a sign of intoxication and disap­pears within some minutes without treatment.

In very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation and disorientation has also been reported. Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in dogs.


Store away from food, drink and animal feeding stuffs. 


Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.


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Very efficient

Fantastic value

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Fantastic value and great delivery. A product i know i can trust.

Would highly recommend

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Quick and reliable service


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Amazing products. They are the best flea drops I have ever tried and they do the job. Great price too and quick delivery. You won’t be disappointed.

no more scracking

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very good price works every time

Great product and service

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I've used advantage for many year's for all my pets and never had a flea problem. It's great value for money and the best value on petshop.co.uk

Flea spot on

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Good price on offer.
All seems fine.

An excellent flea treatment

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I use this flea treatment regularly on my dog and it works. It's easy to put on without getting it on your hands. The price was very good and delivery was quick.

Really good product

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really good product,,its the only thing I use on my dog ...thank you

Happy House

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We recently switched to advantage 400 and I have been really impressed with its performance. Flea free and happy.


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The only product I will use. Does what it has to do.

works as it should

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works great and a lot cheaper than other brands

Flea treatment sorted

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Easy to use - best to apply before bed time as it’s a bit oily on the hair for a while. Well priced and very quick delivery.


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Great product, easy to use fast delivery

Very reliable

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Great service and prompt delivery.

Flea Free

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The product doeas a good job at keeping itchy critters at bay.

Delivery time poor

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It takes too long for delivery...

Brilliant product, brilliant service.

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No fleas here! Made up I found these. Very very similar to what the vet uses, east to apply and so much cheaper! I have set up the 'bottomless bowl' so I don't need to keep reordering. And when I have ran out I know that the next lot will be delivered in time for the next application.

Good.products, change your delivery firm

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Excellent products.
Delivery with Hermes was not good. They didn't knock, didn't leave a card and they took an unhelpful photo


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Very good price and does what it says


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Excellent product does what it says and not overpriced

Great product

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Great product and great price from petshop.co.uk

Better safe than sorry.

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It´s quite pricey compared to other brands, but I trust this manufacturer and I like to go for their products.

Better price than vet

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Very effective when other products were not. Better price than purchasing from vet & quick delivery.


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This is good value, I always prefer Advantage over other flea products. Excellent service and delivery quick.